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PHYSICAL BIOLOGY
Zewail, Ahmed H.
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Últimas novedades
biología
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This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology.
This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function.
The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine.
Contents:
The Preoccupations of Twenty-First-Century Biology (D Baltimore)
The World as Physics, Mathematics and Nothing Else (A Varshavsky)
Physical Biology: 4D Visualization of Complexity (A H Zewail)
Revolutionary Developments from Atomic to Extended Structural Imaging (J M Thomas)
Physical Biology at the Crossroads (C Bustamante)
The Challenge of Quasi-Regular Structures in Biology (R D Kornberg)
The Future of Biological X-Ray Analysis (D C Rees)
Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis (D A Tirrell)
Designing Ligands to Bind Tightly to Proteins (G M Whitesides et al.)
Biology by the Numbers (R Phillips)
Eppur si muove (M Parrinello)
Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space (P G Wolynes)
Protein Folding and Misfolding: From Atoms to Organisms (C M Dobson)
A Systems Approach to Medicine Will Transform Healthcare (L Hood)
The Neurobiology of Consciousness (C Koch & F Mormann)
Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level (J A McCammom)
Precision Measurements in Biology (S R Quake)
Potassium Channels and the Atomic Basis of Selective Ion Conduction (R MacKinnon)
Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems (N S Hush)
The Initial Value Representation of Semiclassical Theory: A Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations of Complex Molecular Systems (W H Miller)
Readership: Graduate students and researchers in life sciences (structural biology, genomics, systems biology, molecular biology, neuroscience), biochemistry, physical chemistry, chemical engineering, and biophysics.
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C o n t e n t s
Prologue by Ahmed H. Zewail xi
Chapter 1 The Preoccupations of Twenty-First-Century Biology 1
David Baltimore
Chapter 2 The World as Physics, Mathematics and Nothing Else 7
Alexander Varshavsky
Chapter 3 Physical Biology: 4D Visualization of Complexity 23
Ahmed H. Zewail
Chapter 4 Revolutionary Developments from Atomic to
Extended Structural Imaging 51
John Meurig Thomas
Chapter 5 Physical Biology at the Crossroads 115
Carlos J. Bustamante
Chapter 6 The Challenge of Quasi-Regular Structures in Biology 137
Roger D. Kornberg
Chapter 7 The Future of Biological X-Ray Analysis 145
Douglas C. Rees
Chapter 8 Reinterpreting the Genetic Code: Implications for
Macromolecular Design, Evolution and Analysis 165
David A. Tirrell
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Contents
Chapter 9 Designing Ligands to Bind Tightly to Proteins 189
George M. Whitesides, Phillip W. Snyder,
Demetri T. Moustakas, and Katherine A. Mirica
Chapter 10 Biology by the Numbers 217
Rob Phillips
Chapter 11 Eppur si muove 247
Michele Parrinello
Chapter 12 Protein Folding and Beyond: Energy Landscapes
and the Organization of Living Matter in
Time and Space 267
Peter G. Wolynes
Chapter 13 Protein Folding and Misfolding: From Atoms to
Organisms 289
Christopher M. Dobson
Chapter 14 A Systems Approach to Medicine Will Transform
Healthcare 337
Leroy Hood
Chapter 15 The Neurobiology of Consciousness 367
Christof Koch and Florian Mormann
Chapter 16 Computer-Aided Drug Discovery: Physics-based
Simulations from the Molecular to the Cellular Level 401
J. Andrew McCammon
Chapter 17 Precision Measurements in Biology 411
Stephen R. Quake
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Contents
Chapter 18 Potassium Channels and the Atomic Basis of Selective
Ion Conduction 431
Roderick MacKinnon
The 2007 Welch Award Papers 463
Chapter 19 Symmetry Breaking, Delocalization and Dynamics in
Electron Transfer Systems 465
Noel S. Hush
Chapter 20 The Initial Value Representation of Semiclassical Theory:
A Practical Way for Adding Quantum Effects to Classical
Molecular Dynamics Simulations of Complex Molecular
Systems 505
William H. Miller
Biographies 527 |
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