This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

Preface.
List of Contributors.

I: HDL Structure.

1. Apolipoprotein A-1 Structure (Michael N. Oda, Robert O. Ryan)

2. Apolipoprotein A-11 (Joan Carles Escola-Gil, Jesus M. Martin-Campos, Josep Julve, Francisco Blanco-Vaca)

3. Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking (Larry L. Swift, Alyssa H. Hasty, MacRae F. Linton, Sergio Fazio)

4. ApoM - A Novel Apolipoprotein with Antiatherogenic Properties (Ning Xu, Peter Nilsson-Ehle)

II: HDL Plasma Metabolic Factors.

5. ATP Binding Cassette Transporters (Laetitia Dufort, Giovanna Chimini)

6. Reverse Cholesterol Transport - New Roles for PreB1HDL and Lecithin: Cholesterol Acyltransferase (Christopher J. Fielding, Phoebe E. Fielding)

7. HDL Remodeling by CETP and SR-BI (Christopher J. Harder, Ruth McPHerson)

8. Human Plasma Phospholipid Transfer Protein (PLTP) - Structural and Functional Features (Sarah Siggins, Kerry-Ann Rye, Vesa M. Olkkonen, Matti Jaugiainen, Christian Ehnholm)

9. Use of Gene Transfer to Study HDL Remodeling (Kazuhiro Oka, Lawerence Chan)

III: HDL Formation, Secretion, Removal.

10. Regulation of Genes Involved in the Biogenesis and the Remodeling of HDL (Dimitris Kardassis, Costas Drosatos, and Vassilis I. Zannis)

11. ApoA-I Functions and Synthesis of HDL: Insights from Mouse Models of Human HDL Metabolism (Vassilis I. Zannis, Eleni E. Zanni, Angeliki Papapanagiotou, Dimitris Kardassis, Christopher J. Fielding, Angeliki Chroni)

12. Hepatic and Renal HDL Receptors (Laurent O. Martinez, Bertrand Perret, Ronald Barbaras, Francois Terce, Xavier Collet)

IV: Biological Activities of HDL.

13. HDL and Inflammation (Mohamad Navab, Srinivasa T. Reddy, Brian J. Van Lenten, Georgette M. Buga, G.M. Anantharamaiah, Alan M. Fogelman)

14. HDL in Health and Disease: Effects of Exercise and HIV Infection on HDL Metabolism (Dmitri Sviri8dov, Michael I. Bukrinsky, Bronwyn A. Kignwell, Jennifer Hoy)

15. Endothelial Protection by High-Density Lipoproteins (Monica Gomaraschi, Laura Calabresi, Guido Granceschini)

16. The Effect of Nutrients on Apolipoprotein A-l Gene Expression (Arshag D. Mooradian)

17. Nutritional Factors and High-Density Lipoprotein Metabolism (Ernst J. Schaefer, Stefania Lamon-Fava, Bela F. Asztalos)

V: Clinical Aspects of HDL.

18. HDL and Metabolic Syndrome (Clara Cavelier, Arnold von Eckardstein)

19. Genetics of High-Density Lipoproteins (Jacques Genest, Zari Dastan, James C. Engert, Michel Marcil)

20. HDL and Atherosclerosis (Philip J. Barter, Kerry-Anne Rye)

21. Therapeutic Targeting of High-Density Lipoproteins (Daniel J. Rader)

Index.