The last quarter of the 20th century saw major scientific revolutions in genetics and computer technology. This book reflects this massive surge in our understanding of the molecular foundations of genetics. In order to understand where these technological advances are heading, there needs to be a basic understanding of how living organisms function at a molecular level. Molecular Biology, 2e, effectively introduces basic concepts followed by more specific applications as the text evolves. With the addition of Cell Press articles, the content is tied to current topics in the scientific community.

Unit 1: Basic Chemical and Biological Principles

Ch1 Cells and Organisms

Ch2 Basic Genetics

Ch3 DNA, RNA, and Protein

Ch4 Genes, Genomes, and DNA

Ch5 Manipulation of Nucleic Acids

Unit 2: The Genome

Ch6 Polymerase Chain Reaction

Ch7 Cloning Genes for Analysis

Ch8 DNA Sequencing

Ch9 Genomics & Systems Biology

Unit 3: The Central Dogma of Molecular Biology

Ch10 Cell Division and DNA Replication

Ch11 Transcription of Genes

Ch12 Processing of RNA

Ch13 Protein Synthesis

Ch14 Protein Structure & Function

Ch15 Proteomics: Global Analysis of Proteins

Unit 4: Regulating Gene Expression

Ch16 Regulation of Transcription in Prokaryotes

Ch17 Regulation of Transcription in Eukaryotes

Ch18 Regulation at RNA Level

Ch19 Analysis of Gene Expression (Transcriptome)

Unit 5: Subcellular Life Forms

Ch20 Plasmids

Ch21 Viruses

Ch22 Mobile DNA

Unit 6: Changing the DNA Blueprint

Ch23 Mutations and Repair

Ch24 Recombination

Ch25 Bacterial Genetics

Ch26 Molecular Evolution